Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 11/20 | 0.38 |
| ▸ | CHRM5 known ✓ | P08912 | 8/20 | 0.38 |
| ▸ | CHRM3 known ✓ | P20309 | 7/20 | 0.38 |
| ▸ | CHRM4 known ✓ | P08173 | 5/20 | 0.38 |
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.35 |
| ▸ | PRKCG | P05129 | 2/20 | 0.35 |
| ▸ | PRKCB | P05771 | 2/20 | 0.35 |
| ▸ | PRKCA | P17252 | 2/20 | 0.35 |
| ▸ | PRKCH | P24723 | 2/20 | 0.35 |
| ▸ | PRKCI | P41743 | 2/20 | 0.35 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5196667 | 0.98 | SLC22A1 (0.43) | SLC22A1ALDH1A1CHRM2CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL587795 | 0.95 | SLC22A1 (0.41) | SLC22A1ALDH1A1CHRM2CHRM5CHRM3 | |
| Iodide SCHEMBL10704645 | 0.95 | CHRM2 (0.42) | SLC22A1ALDH1A1CHRM2CHRM5CHRM3 | |
| Bromide SCHEMBL15210680 | 0.88 | ALDH1A1 (0.52) | SLC22A1ALDH1A1PRKD3PRKCGPRKCB | |
| Hydrochloric Acid SCHEMBL7943589 | 0.86 | SLC22A1 (0.38) | SLC22A1ALDH1A1CHRM2CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL2186924 | 0.84 | ALDH1A1 (0.48) | SLC22A1ALDH1A1PRKD3PRKCGPRKCB | |
| SCHEMBL11125716 | 0.84 | SLC22A1 (0.48) | SLC22A1ALDH1A1CHRM2CHRM5CHRM3 | |
| Hydrochloric Acid SCHEMBL9636325 | 0.82 | SLC22A1 (0.46) | SLC22A1ALDH1A1CHRM2CHRM5CHRM3 | |
| SCHEMBL18260612 | 0.81 | CHRM2 (0.33) | SLC22A1CHRM2CHRM5CHRM3CHRM4 | |
| Hydrochloric Acid SCHEMBL10343542 | 0.80 | SLC22A1 (0.50) | SLC22A1ALDH1A1PRKD3PRKCGPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108729269-A | A kind of active dye fixing agent and preparation method thereof | 李美琴 | 2018-11-02 | — | — | CN | claimed |
| CN-106046647-B | A kind of preparation method of the controllable compatilizer of polarity containing polyfunctional group | 河北工业大学 | 2018-07-31 | — | — | CN | claimed |
| CN-104962026-B | Preparing method of composite compatilizer | 河北工业大学 | 2017-05-03 | — | — | CN | claimed |
| CN-106046647-A | Method for preparing polyfunctional group containing compatilizer with controllable polarity | 河北工业大学 | 2016-10-26 | — | — | CN | claimed |
| CN-108059733-B | Porous film-forming composition, separator, electrochemical element, and method for producing electrode composite | 东京应化工业株式会社 | 2021-10-26 | — | — | CN | disclosed |
| CN-105940156-B | Stabilize sizing preparation | 凯米罗总公司 | 2019-05-10 | — | — | CN | disclosed |
| US-10132038-B2 | Stabilized sizing formulation | KEMIRA OYJ (FI) | 2018-11-20 | — | — | US | disclosed |
| CN-108729269-A | A kind of active dye fixing agent and preparation method thereof | 李美琴 | 2018-11-02 | — | — | CN | disclosed |
| CN-106046647-B | A kind of preparation method of the controllable compatilizer of polarity containing polyfunctional group | 河北工业大学 | 2018-07-31 | — | — | CN | disclosed |
| CN-108059733-A | Porous-film-forming composition, membrane, the manufacturing method of electrochemical element and electrode complex | 东京应化工业株式会社 | 2018-05-22 | — | — | CN | disclosed |
| EP-3102736-B1 | A STABILIZED SIZING FORMULATION | KEMIRA OYJ (FI) | 2017-11-22 | — | — | EP | disclosed |
| CN-104962026-B | Preparing method of composite compatilizer | 河北工业大学 | 2017-05-03 | — | — | CN | disclosed |
| EP-3102736-A1 | A STABILIZED SIZING FORMULATION | Kemira OYJ (FI) | 2016-12-14 | — | — | EP | disclosed |
| US-20160348317-A1 | A stalilized sizing formulation | KEMIRA OYJ (FI) | 2016-12-01 | — | — | US | disclosed |
| CN-106046647-A | Method for preparing polyfunctional group containing compatilizer with controllable polarity | 河北工业大学 | 2016-10-26 | — | — | CN | disclosed |
| CN-105940156-A | Stabilized sizing formulation | 凯米罗总公司 | 2016-09-14 | — | — | CN | disclosed |