Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 9/20 | 0.66 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18263116 | 0.83 | FYN (0.69) | FYNCHEK2MAP4K4DYRK1ATGFBR1 | |
| SCHEMBL18240070 | 0.81 | FYN (0.58) | FYNCHEK2MAP4K4CLK1 | |
| SCHEMBL28824279 | 0.80 | FYN (0.57) | FYNCHEK2MAP4K4DYRK1ATGFBR1 | |
| SCHEMBL18613248 | 0.80 | FYN (1.00) | FYNCHEK2TGFBR1 | |
| SCHEMBL27902100 | 0.78 | KCNH2 (0.70) | FYNCHEK2MAP4K4TGFBR1 | |
| SCHEMBL488290 | 0.78 | IKBKE (0.59) | FYNCHEK2MAP4K4PDGFRB | |
| SCHEMBL28790793 | 0.78 | FYN (0.48) | FYNCHEK2TGFBR1TP53MAPK1 | |
| SCHEMBL18263118 | 0.77 | MAP4K4 (0.58) | MAP4K4 | |
| SCHEMBL18263141 | 0.77 | FYN (0.57) | FYNCHEK2MAP4K4DYRK1ACLK1 | |
| SCHEMBL488494 | 0.77 | USP7 (0.62) | FYNCHEK2MAP4K4MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145935-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | Universiteit Leiden (NL) | 2017-03-29 | — | — | EP | disclosed |
| WO-2016188972-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | UNIVERSITEIT LEIDEN (NL) | 2016-12-01 | — | — | WO | disclosed |
| WO-2016188972-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | UNIVERSITEIT LEIDEN (NL) | 2016-12-01 | — | — | WO | disclosed |