Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 6/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | USP7 | Q93009 | 3/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.48 |
| ▸ | VRK2 | Q86Y07 | 1/20 | 0.47 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | IL4 | P05112 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18263126 | 0.82 | FYN (0.58) | FYNMAP4K4USP7EGLN1CHEK2 | |
| SCHEMBL18263118 | 0.81 | MAP4K4 (0.58) | MAP4K4USP7EGLN1CHRNA7 | |
| SCHEMBL18240070 | 0.81 | FYN (0.58) | FYNMAP4K4USP7EGLN1CLK1 | |
| SCHEMBL488494 | 0.81 | USP7 (0.62) | FYNMAP4K4USP7EGLN1CHEK2 | |
| SCHEMBL1582343 | 0.81 | MAP4K4 (0.54) | FYNMAP4K4USP7VRK2VRK1 | |
| SCHEMBL15614331 | 0.81 | EGLN1 (0.50) | FYNMAP4K4USP7EGLN1CLK1 | |
| SCHEMBL18263155 | 0.81 | MAP4K4 (0.58) | MAP4K4USP7CLK1 | |
| SCHEMBL1091494 | 0.78 | MAP4K4 (0.51) | FYNMAP4K4USP7VRK2HDAC1 | |
| SCHEMBL17016659 | 0.78 | EGLN1 (0.48) | FYNMAP4K4EGLN1VRK1CLK1 | |
| SCHEMBL18263129 | 0.77 | FYN (0.66) | FYNMAP4K4CLK1DYRK1ACHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145935-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | Universiteit Leiden (NL) | 2017-03-29 | — | — | EP | disclosed |
| WO-2016188972-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | UNIVERSITEIT LEIDEN (NL) | 2016-12-01 | — | — | WO | disclosed |
| WO-2016188972-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS | UNIVERSITEIT LEIDEN (NL) | 2016-12-01 | — | — | WO | disclosed |