Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26622028 | 0.91 | HSD17B10 (0.49) | HSD17B10TSHRJAK2JAK1TYK2 | |
| SCHEMBL1851435 | 0.90 | HSD17B10 (0.48) | HSD17B10TSHRJAK2JAK1TYK2 | |
| SCHEMBL1855350 | 0.89 | HSD17B10 (0.47) | HSD17B10TSHRJAK2JAK1TYK2 | |
| SCHEMBL18264010 | 0.89 | HSD17B10 (0.47) | HSD17B10TSHRJAK2JAK1TYK2 | |
| SCHEMBL32672337 | 0.88 | JAK2 (0.48) | HSD17B10TSHRJAK2JAK1TYK2 | |
| SCHEMBL32672455 | 0.82 | JAK2 (0.44) | HSD17B10TSHRJAK2JAK1TYK2 | |
| SCHEMBL18264031 | 0.81 | ALDH1A1 (0.54) | HSD17B10TSHRJAK2JAK1TYK2 | |
| SCHEMBL29443049 | 0.79 | KDM4E (0.57) | HSD17B10TSHRJAK2JAK1TYK2 | |
| SCHEMBL15595465 | 0.79 | KDM4E (0.57) | HSD17B10TSHRJAK2JAK1TYK2 | |
| SCHEMBL18264006 | 0.78 | HDAC3 (0.43) | HSD17B10TSHRJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016191366-A1 | MODULATORS FOR NICOTINIC ACETYLCHOLINE RECEPTOR α2 AND α4 SUBUNITS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-12-01 | — | — | WO | disclosed |
| WO-2016191366-A1 | MODULATORS FOR NICOTINIC ACETYLCHOLINE RECEPTOR α2 AND α4 SUBUNITS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-12-01 | — | — | WO | disclosed |