Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1826572 | 1.00 | PDE10A (0.43) | PDE10AHCRTR1HCRTR2LMNASTAT3 | |
| SCHEMBL1141579 | 0.83 | HCRTR1 (0.48) | PDE10AHCRTR1HCRTR2LMNASSTR5 | |
| SCHEMBL1141576 | 0.83 | HCRTR1 (0.48) | PDE10AHCRTR1HCRTR2LMNASSTR5 | |
| SCHEMBL14775828 | 0.80 | PDE10A (0.44) | PDE10ACCR5 | |
| SCHEMBL14775830 | 0.80 | PDE10A (0.44) | PDE10ACCR5 | |
| SCHEMBL1141112 | 0.76 | HCRTR1 (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL1141109 | 0.76 | HCRTR1 (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL16538487 | 0.76 | PDE10A (0.54) | PDE10ASSTR5 | |
| SCHEMBL1838143 | 0.75 | CCNK (0.42) | CCR5 | |
| SCHEMBL4241757 | 0.75 | HCRTR1 (0.51) | HCRTR1HCRTR2LMNACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318367-A1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-11 | — | — | EP | disclosed |
| WO-2009133522-A1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2009-11-05 | — | — | WO | disclosed |