Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.44 |
| ▸ | HTR2B | P41595 | 4/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.42 |
| ▸ | ITGAV | P06756 | 4/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14775830 | 1.00 | PDE10A (0.44) | PDE10AHTR2BITGB3ITGAVHRH4 | |
| SCHEMBL1141655 | 0.82 | CDK4 (0.49) | PDE10AHTR2BBACE1BACE2 | |
| SCHEMBL1141659 | 0.82 | CDK4 (0.49) | PDE10AHTR2BBACE1BACE2 | |
| SCHEMBL9690986 | 0.80 | SMN1; SMN2 (0.51) | KCNH2SMN1; SMN2 | |
| SCHEMBL1826572 | 0.80 | PDE10A (0.43) | PDE10ACCR5 | |
| SCHEMBL1826569 | 0.80 | PDE10A (0.43) | PDE10ACCR5 | |
| Hydrochloric Acid SCHEMBL9382986 | 0.79 | SMN1; SMN2 (0.50) | KCNH2SMN1; SMN2 | |
| SCHEMBL9630086 | 0.77 | NOS2 (0.51) | ITGB3ITGAVKCNH2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9594900 | 0.76 | NOS2 (0.50) | ITGB3ITGAVKCNH2SMN1; SMN2 | |
| SCHEMBL8139051 | 0.76 | SMN1; SMN2 (0.53) | KCNH2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318367-B1 | PIPERIDINE AND PYRROLIDINE COMPOUNDS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-03-20 | — | — | EP | disclosed |