Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.49 |
| ▸ | GSK3B | P49841 | 11/20 | 0.47 |
| ▸ | GSK3A | P49840 | 6/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | PRKACG | P22612 | 1/20 | 0.45 |
| ▸ | PRKACB | P22694 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713938 | 0.93 | GSK3B (0.55) | ROCK2ROCK1GSK3BGSK3ABRAF | |
| SCHEMBL18266214 | 0.89 | ROCK1 (0.49) | ROCK2ROCK1GSK3BGSK3APRKG1 | |
| SCHEMBL2714843 | 0.88 | GSK3B (0.54) | ROCK2ROCK1GSK3BGSK3ABRAF | |
| SCHEMBL18266794 | 0.87 | ROCK2 (0.47) | ROCK2ROCK1GSK3BGSK3ABRAF | |
| SCHEMBL2717508 | 0.86 | ROCK2 (0.49) | ROCK2ROCK1GSK3BGSK3ABRAF | |
| SCHEMBL2715734 | 0.86 | ROCK2 (0.49) | ROCK2ROCK1GSK3BGSK3ABRAF | |
| SCHEMBL15351218 | 0.86 | GSK3B (0.51) | ROCK2ROCK1GSK3BGSK3ABRAF | |
| SCHEMBL2715733 | 0.86 | ROCK2 (0.49) | ROCK2ROCK1GSK3BGSK3ABRAF | |
| SCHEMBL18266117 | 0.84 | ACACB (0.51) | GSK3BGSK3AMAPT | |
| SCHEMBL2715498 | 0.83 | GSK3B (0.58) | GSK3BGSK3AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630122-B1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2016-11-30 | — | — | EP | disclosed |