Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714691 | 0.94 | RIPK1 (0.48) | SCN9ARIPK1ADORA2AADORA2BADORA1 | |
| SCHEMBL18266494 | 0.89 | RIPK1 (0.42) | SCN9ARIPK1ADORA2AADORA2BADORA1 | |
| SCHEMBL18266542 | 0.89 | RIPK1 (0.42) | SCN9ARIPK1ADORA2AADORA2BADORA1 | |
| SCHEMBL2714773 | 0.85 | SCN9A (0.50) | SCN9ACHRM4EPHX2ALDH1A1MEN1 | |
| SCHEMBL2715976 | 0.84 | RIPK1 (0.57) | RIPK1ADORA2AADORA2BADORA1EPHX2 | |
| SCHEMBL18266303 | 0.84 | SCN9A (0.47) | SCN9ARIPK1CHRM4KCNB1MAPT | |
| SCHEMBL2715536 | 0.84 | RIPK1 (0.48) | SCN9ARIPK1ADORA2AADORA2BADORA1 | |
| SCHEMBL18266538 | 0.83 | KCNB1 (0.50) | SCN9ARIPK1KCNB1GSK3BPPARG | |
| SCHEMBL2714267 | 0.83 | RIPK1 (0.48) | RIPK1ADORA2AADORA2BADORA1EPHX2 | |
| SCHEMBL18266345 | 0.83 | SCN9A (0.48) | SCN9ARIPK1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630122-B1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2016-11-30 | — | — | EP | disclosed |