Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714068 | 0.93 | P2RX7 (0.47) | TYK2P2RX7EPHX2BRAFKDR | |
| SCHEMBL18266662 | 0.90 | ERCC1 (0.39) | TYK2JAK1JAK2 | |
| SCHEMBL18266639 | 0.86 | EPHX2 (0.43) | P2RX7EPHX2 | |
| SCHEMBL2715917 | 0.84 | NR3C2 (0.48) | P2RX7BRAFKDRJAK2 | |
| SCHEMBL18266530 | 0.84 | EPHX2 (0.40) | TYK2P2RX7EPHX2BRAFKDR | |
| SCHEMBL2716568 | 0.83 | SCN3A (0.51) | TYK2P2RX7BRAFKDRROCK2 | |
| SCHEMBL2716987 | 0.81 | BRAF (0.44) | BRAFKDRROCK2 | |
| SCHEMBL2715430 | 0.80 | AURKA (0.45) | BRAF | |
| SCHEMBL18266529 | 0.80 | PPARG (0.39) | BRAFKDR | |
| SCHEMBL2716082 | 0.80 | EPHX2 (0.47) | P2RX7EPHX2BRAFKDRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630122-B1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2016-11-30 | — | — | EP | disclosed |