Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180648 | 0.84 | DGAT1 (0.57) | DGAT1HDAC3HDAC1HDAC2 | |
| SCHEMBL180444 | 0.78 | DGAT1 (0.62) | PTGIRDGAT1 | |
| SCHEMBL180333 | 0.73 | DGAT1 (0.58) | DGAT1 | |
| SCHEMBL180656 | 0.71 | DGAT1 (0.55) | DGAT1 | |
| SCHEMBL180940 | 0.71 | DGAT1 (0.54) | DGAT1HDAC3HDAC1HDAC2 | |
| SCHEMBL181151 | 0.69 | DGAT1 (0.60) | DGAT1HDAC1HDAC2 | |
| SCHEMBL181270 | 0.68 | DGAT1 (0.56) | DGAT1 | |
| SCHEMBL180661 | 0.67 | DGAT1 (0.58) | DGAT1 | |
| SCHEMBL17346623 | 0.66 | PTGIR (0.81) | PTGIRBCHEMAOBACHECHRM3 | |
| SCHEMBL180538 | 0.65 | DGAT1 (0.55) | DGAT1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402320-A1 | Anorectic agents | Novartis AG (CH) | 2012-01-04 | — | — | EP | disclosed |