Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ACR | P10323 | 1/20 | 0.48 |
| ▸ | IL2 | P60568 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16363165 | 0.90 | NPC1 (0.64) | NPC1RAB9AALDH1A1HTTTP53 | |
| SCHEMBL5188882 | 0.86 | NPC1 (0.71) | NPC1RAB9AALDH1A1HTTTP53 | |
| SCHEMBL2785179 | 0.84 | MAPT (0.44) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL1826603 | 0.83 | GFER (0.52) | NPC1RAB9AALDH1A1HTTTP53 | |
| SCHEMBL1826746 | 0.81 | RAB9A (0.73) | NPC1RAB9AHTTTP53SMN1; SMN2 | |
| SCHEMBL1827469 | 0.81 | NPC1 (0.46) | NPC1RAB9AHTTTP53SMN1; SMN2 | |
| SCHEMBL1827786 | 0.80 | RXFP2 (0.52) | NPC1RAB9AHTTTP53SMN1; SMN2 | |
| SCHEMBL1827556 | 0.78 | MAPT (0.57) | NPC1RAB9AALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL8267173 | 0.78 | NPC1 (0.90) | NPC1RAB9AALDH1A1HTTTP53 | |
| SCHEMBL8297621 | 0.77 | RXFP1 (0.57) | NPC1RAB9AALDH1A1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2319516-A1 | Compounds for treating inflammatory and autoimmune disorders | Synta Pharmaceuticals Corp. (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-2319516-A1 | Compounds for treating inflammatory and autoimmune disorders | Synta Pharmaceuticals Corp. (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2005009954-A2 | METHOD FOR MODULATING CALCIUM ION-RELEASE-ACTIVATED CALCIUM ION CHANNELS | SYNTA PHARMACEUTICALS, CORP. (US) | 2005-02-03 | — | — | WO | disclosed |
| WO-2005009539-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS, CORP. (US) | 2005-02-03 | — | — | WO | disclosed |