Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.78 |
| ▸ | JAK1 | P23458 | 17/20 | 0.78 |
| ▸ | JAK3 | P52333 | 14/20 | 0.78 |
| ▸ | CIT | O14578 | 1/20 | 0.78 |
| ▸ | GAK | O14976 | 1/20 | 0.78 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.78 |
| ▸ | ULK1 | O75385 | 1/20 | 0.78 |
| ▸ | PRKCB | P05771 | 1/20 | 0.78 |
| ▸ | RET | P07949 | 1/20 | 0.78 |
| ▸ | PRKCA | P17252 | 1/20 | 0.78 |
| ▸ | PRKACA | P17612 | 1/20 | 0.78 |
| ▸ | MARK3 | P27448 | 1/20 | 0.78 |
| ▸ | TYK2 | P29597 | 1/20 | 0.78 |
| ▸ | STAT3 | P40763 | 1/20 | 0.78 |
| ▸ | CLK1 | P49759 | 1/20 | 0.78 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.78 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.78 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.78 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.78 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15218749 | 0.90 | JAK2 (0.78) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL18271131 | 0.90 | JAK2 (0.75) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL29541207 | 0.89 | JAK2 (0.83) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL100609 | 0.89 | JAK2 (0.83) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL22730713 | 0.88 | JAK2 (0.70) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL22730915 | 0.88 | JAK2 (0.70) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL871544 | 0.88 | JAK2 (0.72) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL871842 | 0.88 | JAK2 (0.80) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL2605490 | 0.88 | JAK2 (0.74) | JAK2JAK1JAK3CITGAK | |
| SCHEMBL100359 | 0.88 | JAK2 (0.83) | JAK2JAK1JAK3CITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021053690-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BARICITINIB | NATCO PHARMA LIMITED (IN) | 2021-03-25 | — | — | WO | disclosed |
| US-20200397774-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE HOLDINGS CORPORATION | 2020-12-24 | — | — | US | disclosed |
| WO-2017082759-A1 | {3-[(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-AZOLYL]AZETIDIN-3-YL}-ACETONITRILES AS JANUS KINASE INHIBITORS | АКЦИОНЕРНОЕ ОБЩЕСТВО "Р-ФАРМ" (АО "Р-ФАРМ") | 2017-05-18 | — | — | WO | disclosed |
| US-20160347734-A1 | PROCESSES AND INTERMEDIATES FOR MAKING A JAK INHIBITOR | INCYTE CORPORATION (US) | 2016-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200397774-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | JAK1, JAK2, JAK3 | JAK2 2/4885JAK1 1/4885JAK3 3/4885 |
| US-20160347734-A1 | PROCESSES AND INTERMEDIATES FOR MAKING A JAK INHIBITOR | JAK1, JAK2, JAK3 | JAK2 2/4885JAK1 1/4885JAK3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.