Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18269652 | 1.00 | LMNA (0.51) | LMNAPOLBALDH1A1MGLLUSP2 | |
| SCHEMBL9245030 | 0.95 | LMNA (0.57) | LMNAPOLBALDH1A1USP2ALOX15 | |
| SCHEMBL28992338 | 0.91 | LMNA (0.56) | LMNAPOLBALDH1A1MGLLUSP2 | |
| SCHEMBL28992225 | 0.89 | LMNA (0.55) | LMNAPOLBALDH1A1MGLLUSP2 | |
| SCHEMBL18269647 | 0.89 | LMNA (0.55) | LMNAPOLBALDH1A1MGLLUSP2 | |
| SCHEMBL4994207 | 0.88 | LMNA (0.43) | LMNAPOLBALDH1A1MGLL | |
| SCHEMBL28992190 | 0.86 | LMNA (0.62) | LMNAPOLBALDH1A1USP2ALOX15 | |
| SCHEMBL28992336 | 0.84 | LMNA (0.60) | LMNAPOLBALDH1A1MGLLUSP2 | |
| SCHEMBL1961403 | 0.83 | POLB (0.46) | LMNAPOLBALDH1A1 | |
| SCHEMBL5899164 | 0.83 | LMNA (0.46) | LMNAPOLBALDH1A1USP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9771358-B2 | Dihydropyrimidine compounds and their application in pharmaceuticals | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2017-09-26 | — | — | US | disclosed |
| US-20160347746-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347746-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS | DPYD, SLC10A1, HPRT1 | LMNA 1975/4885POLB 290/4885ALDH1A1 828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.