Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 8/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182961 | 0.78 | USP2 (0.50) | CYP1A2CYP3A4KDM4EACVR1CLK4 | |
| SCHEMBL182963 | 0.77 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL182851 | 0.77 | PIK3CD (0.52) | CYP1A2CYP3A4KDM4ECLK4CYP2C19 | |
| SCHEMBL183522 | 0.77 | PIK3CD (0.52) | CYP1A2CYP3A4KDM4ECLK4CYP2C19 | |
| SCHEMBL182816 | 0.76 | MAP4K1 (0.61) | CYP1A2CYP3A4KDM4EACVR1CLK4 | |
| SCHEMBL182950 | 0.75 | MAP4K1 (0.60) | CYP1A2CYP3A4KDM4EACVR1CLK4 | |
| SCHEMBL182925 | 0.73 | PIK3CD (0.55) | CYP1A2CYP3A4KDM4ECLK4CYP2C19 | |
| SCHEMBL14883835 | 0.71 | PIK3CD (0.71) | CYP1A2CYP3A4KDM4ECLK4CYP2C19 | |
| Tert-Butyl Formate SCHEMBL27767933 | 0.69 | MAP4K1 (0.53) | CYP1A2CYP3A4CLK4CYP2C19USP2 | |
| SCHEMBL15244897 | 0.69 | KCNH2 (0.56) | BMPR1BBMPR1AACVR1ACVRL1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |
| US-20090258882-A1 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors | NOVARTIS AG | 2009-10-15 | — | — | US | claimed |
| EP-2049502-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | Novartis AG (CH) | 2009-04-22 | — | — | EP | claimed |
| WO-2008012326-A1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-31 | — | — | WO | claimed |
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258882-A1 | 2,4-Substituted Quinazolines as Lipid Kinase Inhibitors | PDPK1, PI4KA, PIK3CA | CYP1A2 622/4885CYP3A4 1218/4885KDM4E 1674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.