Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.53 |
| ▸ | IL2 | P60568 | 3/20 | 0.53 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MELK | Q14680 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27767858 | 0.97 | MAP4K1 (0.51) | MAP4K1IL2TLR8TLR7TLR9 | |
| SCHEMBL182816 | 0.91 | MAP4K1 (0.61) | MAP4K1IL2TLR8TLR7TLR9 | |
| SCHEMBL182950 | 0.89 | MAP4K1 (0.60) | MAP4K1IL2TLR8TLR7TLR9 | |
| SCHEMBL182761 | 0.81 | PIK3CD (0.57) | TLR8TLR7PIK3CDPIK3CAPIK3CB | |
| SCHEMBL322733 | 0.80 | PIK3CD (0.50) | MAP4K1IL2TLR8TLR7TLR9 | |
| SCHEMBL182851 | 0.79 | PIK3CD (0.52) | MAP4K1IL2TLR8TLR7TLR9 | |
| SCHEMBL183522 | 0.79 | PIK3CD (0.52) | MAP4K1IL2TLR8TLR7TLR9 | |
| SCHEMBL27767931 | 0.79 | PIK3CD (0.51) | MAP4K1IL2TLR8TLR7TLR9 | |
| SCHEMBL182904 | 0.78 | PIK3CD (0.57) | TLR8TLR7PIK3CDPIK3CAPIK3CB | |
| SCHEMBL28776662 | 0.78 | TLR8 (0.50) | MAP4K1IL2TLR8TLR7TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101490016-A | 2,4-substituted quinazolines as lipid kinase inhibitors | NOVARTIS AG (CH) | 2009-07-22 | — | — | CN | claimed |
| CN-101490016-A | 2,4-substituted quinazolines as lipid kinase inhibitors | NOVARTIS AG (CH) | 2009-07-22 | — | — | CN | disclosed |