Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 1.00 |
| ▸ | PTPN6 | P29350 | 3/20 | 1.00 |
| ▸ | PTPN11 | Q06124 | 3/20 | 1.00 |
| ▸ | ACP1 | P24666 | 12/20 | 0.57 |
| ▸ | PTPN12 | Q05209 | 4/20 | 0.55 |
| ▸ | PTPN13 | Q12923 | 3/20 | 0.55 |
| ▸ | SSU72 | Q9NP77 | 3/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18281591 | 0.91 | PTPN1 (0.86) | PTPN1PTPN6PTPN11ACP1PTPN12 | |
| SCHEMBL18289745 | 0.87 | PTPN1 (1.00) | PTPN1PTPN6PTPN11ACP1PTPN12 | |
| SCHEMBL18281617 | 0.87 | PTPN1 (0.79) | PTPN1PTPN6PTPN11ACP1PTPN12 | |
| SCHEMBL20281420 | 0.86 | PTPN1 (0.78) | PTPN1PTPN6PTPN11ACP1PTPN12 | |
| SCHEMBL18281593 | 0.85 | PTPN1 (1.00) | PTPN1PTPN6PTPN11ACP1PTPN12 | |
| SCHEMBL18291877 | 0.82 | PTPN1 (0.91) | PTPN1PTPN6PTPN11ACP1PTPN12 | |
| SCHEMBL20281609 | 0.81 | PTPN1 (0.71) | PTPN1PTPN6PTPN11ACP1PTPN12 | |
| SCHEMBL18281601 | 0.79 | PTPN1 (0.73) | PTPN1PTPN6PTPN11ACP1PTPN12 | |
| SCHEMBL18281579 | 0.78 | PTPN11 (0.65) | PTPN1PTPN6PTPN11ACP1PTPN12 | |
| SCHEMBL18281588 | 0.76 | PTPN1 (0.63) | PTPN1PTPN6PTPN11ACP1PTPN12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2018-06-21 | — | — | US | disclosed |
| WO-2016196569-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016196569-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016196591-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016196591-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170861-A1 | SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF | PTPA, EPM2A, PTPRA | PTPN1 33/4885PTPN6 28/4885PTPN11 60/4885 |
| US-20180170862-A1 | PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF | PTPA, PTPRA, PTPRCAP | PTPN1 22/4885PTPN6 23/4885PTPN11 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.