Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1292072 | 0.86 | APEX1 (0.60) | APEX1LMNANPC1RAB9APOLB | |
| SCHEMBL13832486 | 0.83 | APEX1 (0.57) | APEX1NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL13833586 | 0.80 | LMNA (0.60) | APEX1LMNANPC1RAB9APOLB | |
| SCHEMBL13833602 | 0.77 | LMNA (0.70) | APEX1LMNANPC1RAB9APOLB | |
| SCHEMBL4710248 | 0.77 | KDM4E (0.49) | LMNANPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL13833639 | 0.76 | LMNA (0.63) | APEX1LMNANPC1RAB9APOLB | |
| SCHEMBL13833702 | 0.74 | LMNA (0.59) | APEX1LMNANPC1RAB9APOLB | |
| SCHEMBL13833590 | 0.74 | APEX1 (0.77) | APEX1LMNANPC1RAB9APOLB | |
| SCHEMBL13833641 | 0.74 | LMNA (0.63) | APEX1LMNANPC1RAB9APOLB | |
| SCHEMBL13833669 | 0.74 | LMNA (0.66) | APEX1LMNANPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196910-A1 | COMPOUNDS FOR THE MODULATION OF MYC ACTIVITY | SYROS PHARMACEUTICALS, INC. (US) | 2016-12-08 | — | — | WO | disclosed |