Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1615151 | 0.87 | RXFP1 (0.43) | RXFP1FFAR1FFAR4MAPTSMN1; SMN2 | |
| SCHEMBL1823520 | 0.85 | TUBB4A (0.48) | RXFP1MAPTTP53 | |
| SCHEMBL1825063 | 0.81 | TUBB4A (0.43) | MAPTSMN1; SMN2KMT2AEGFRMEN1 | |
| SCHEMBL1823740 | 0.81 | TUBB4A (0.38) | MAPTLMNAKMT2AAURKARPS6KB1 | |
| SCHEMBL1824781 | 0.80 | TUBB4A (0.44) | MAPTSMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL1826034 | 0.80 | FFAR1 (0.38) | FFAR1FFAR4MAPTKMT2AMEN1 | |
| SCHEMBL1823610 | 0.79 | TP53 (0.40) | RXFP1MAPTPPARAKMT2AAURKA | |
| SCHEMBL1827112 | 0.79 | HDAC6 (0.46) | KDRFLT1ALDH1A1 | |
| SCHEMBL1825597 | 0.78 | TUBB4A (0.42) | MAPTSMN1; SMN2LMNAKMT2AALDH1A1 | |
| SCHEMBL1827155 | 0.78 | TUBB4A (0.42) | RXFP1MAPTSMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794122-B1 | 3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I | AVENTIS PHARMA INC (US) | 2011-05-04 | — | — | EP | claimed |