Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | RPLP1 | P05386 | 2/20 | 0.41 |
| ▸ | RPLP0 | P05388 | 2/20 | 0.41 |
| ▸ | RPS17 | P08708 | 2/20 | 0.41 |
| ▸ | RPSA | P08865 | 2/20 | 0.41 |
| ▸ | RPS2 | P15880 | 2/20 | 0.41 |
| ▸ | RPL35A | P18077 | 2/20 | 0.41 |
| ▸ | RPL7 | P18124 | 2/20 | 0.41 |
| ▸ | RPL17 | P18621 | 2/20 | 0.41 |
| ▸ | RPS4Y1 | P22090 | 2/20 | 0.41 |
| ▸ | RPS3 | P23396 | 2/20 | 0.41 |
| ▸ | RPS12 | P25398 | 2/20 | 0.41 |
| ▸ | RPL13 | P26373 | 2/20 | 0.41 |
| ▸ | RPL10 | P27635 | 2/20 | 0.41 |
| ▸ | RPL12 | P30050 | 2/20 | 0.41 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 2/20 | 0.41 |
| ▸ | RPL22 | P35268 | 2/20 | 0.41 |
| ▸ | RPL4 | P36578 | 2/20 | 0.41 |
| ▸ | RPS19 | P39019 | 2/20 | 0.41 |
| ▸ | RPL3 | P39023 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29471047 | 0.90 | KMT2A (0.44) | KMT2AMEN1BLMATMTP53 | |
| SCHEMBL18285501 | 0.84 | RPLP1 (0.42) | KCNH2RPLP1RPLP0RPS17RPSA | |
| SCHEMBL18285592 | 0.81 | GFER (0.42) | KMT2ANPC1 | |
| SCHEMBL18285588 | 0.81 | GFER (0.42) | KMT2ANPC1 | |
| SCHEMBL18285596 | 0.81 | GFER (0.42) | KMT2ANPC1 | |
| SCHEMBL2707665 | 0.79 | NPC1 (0.41) | KCNH2RPS6KB1KMT2AMEN1NPC1 | |
| SCHEMBL25981785 | 0.79 | BTK (0.36) | BTK | |
| SCHEMBL23450710 | 0.78 | ALDH1A1 (0.41) | KMT2AMEN1BTK | |
| SCHEMBL18290014 | 0.78 | ALDH1A1 (0.41) | KMT2AMEN1BTK | |
| SCHEMBL30111806 | 0.78 | ALDH1A1 (0.41) | KMT2AMEN1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303334-A1 | TYROSINE KINASE INHIBITORS | Principia Biopharma Inc. (US) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016196840-A1 | TYROSINE KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2016-12-08 | — | — | WO | disclosed |