Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | TEC | P42680 | 1/20 | 0.37 |
| ▸ | CD69 | Q07108 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28484529 | 0.90 | BTK (0.54) | BTKEGFRTECCD69HRH3 | |
| SCHEMBL18285607 | 0.89 | BTK (0.54) | BTKEGFRTECCD69HRH3 | |
| SCHEMBL18285610 | 0.89 | BTK (0.54) | BTKEGFRTECCD69HRH3 | |
| SCHEMBL18818235 | 0.77 | BTK (0.58) | BTKEGFRTECCD69 | |
| SCHEMBL18818236 | 0.77 | BTK (0.58) | BTKEGFRTECCD69 | |
| SCHEMBL23450721 | 0.75 | BTK (0.57) | BTKEGFRTECCD69 | |
| SCHEMBL30111802 | 0.75 | BTK (0.57) | BTKEGFRTECCD69 | |
| SCHEMBL28484312 | 0.72 | HRH3 (0.42) | BTKHRH3FFAR1 | |
| SCHEMBL18285658 | 0.71 | BTK (0.69) | BTKEGFRTECCD69 | |
| SCHEMBL30866994 | 0.71 | BTK (0.69) | BTKEGFRTECCD69 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303334-A1 | TYROSINE KINASE INHIBITORS | Principia Biopharma Inc. (US) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016196840-A1 | TYROSINE KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2016-12-08 | — | — | WO | disclosed |