Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554125 | 0.75 | ALDH1A1 (0.38) | ELANEALDH1A1GAAKMT2ATSHR | |
| SCHEMBL1833492 | 0.75 | ALDH1A1 (0.38) | ELANEALDH1A1GAAKMT2ATSHR | |
| SCHEMBL11569756 | 0.72 | ELANE (0.61) | ELANEATMALDH1A1ITGALLMNA | |
| SCHEMBL13879447 | 0.72 | ELANE (0.57) | ELANEATMKMT2AL3MBTL1LMNA | |
| SCHEMBL5147324 | 0.72 | ATM (0.49) | ELANEATMALDH1A1ITGALGAA | |
| SCHEMBL29195204 | 0.71 | ELANE (0.46) | ELANEATMALDH1A1 | |
| SCHEMBL1710660 | 0.71 | BACE1 (0.46) | ELANEBACE1OPRM1SIGMAR1ALDH1A1 | |
| SCHEMBL15973468 | 0.69 | ATM (0.59) | ATMALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL15973467 | 0.69 | ATM (0.59) | ATMALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL3127344 | 0.68 | EPHX2 (0.54) | ELANEOPRM1ALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144336-A1 | Method for Preparation of Piperazindione Derivatives | BASF SE (DE) | 2011-06-16 | — | — | US | disclosed |
| EP-2318379-A1 | METHOD FOR PREPARATION OF PIPERAZINDIONE DERIVATES | BASF SE (DE) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010018067-A1 | METHOD FOR PREPARATION OF PIPERAZINDIONE DERIVATES | BASF SE (DE) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144336-A1 | Method for Preparation of Piperazindione Derivatives | H1-0, H1-3, H1-2 | ELANE 2208/4885BACE1 4592/4885ATM 2248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.