Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.60 |
| ▸ | FYN | P06241 | 3/20 | 0.55 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | LDHB | P07195 | 1/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 3/20 | 0.47 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205401 | 0.92 | CSF1R (0.59) | CSF1RFYNBRAFLDHALDHB | |
| SCHEMBL5208271 | 0.92 | FYN (0.67) | CSF1RFYNBRAFLDHALDHB | |
| SCHEMBL5934776 | 0.92 | FYN (0.67) | CSF1RFYNBRAFLDHALDHB | |
| SCHEMBL5205798 | 0.91 | CSF1R (0.65) | CSF1RFYNBRAFLDHALDHB | |
| SCHEMBL5208442 | 0.91 | CSF1R (0.65) | CSF1RFYNBRAFLDHALDHB | |
| SCHEMBL12104596 | 0.88 | CSF1R (0.66) | CSF1RFYNBRAFLDHALDHB | |
| SCHEMBL12064805 | 0.86 | CCNC (0.53) | CSF1RFYNBRAFCCNT1CDK9 | |
| SCHEMBL5208910 | 0.86 | CSF1R (0.67) | CSF1RFYNBRAFLDHALDHB | |
| SCHEMBL18286644 | 0.84 | CCNC (0.51) | CSF1RFYNBRAFCCNT1CDK9 | |
| SCHEMBL12056827 | 0.84 | CCNC (0.51) | CSF1RFYNBRAFCCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569917-B1 | PYRAZINE-BASED TUBULIN INHIBITORS | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2016-12-07 | — | — | EP | disclosed |