Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 4/20 | 0.50 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 3/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.46 |
| ▸ | CDK9 | P50750 | 9/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12056827 | 1.00 | CCNC (0.51) | CCNCCDK8FYNBRAFCSF1R | |
| SCHEMBL12056845 | 1.00 | CCNC (0.51) | CCNCCDK8FYNBRAFCSF1R | |
| SCHEMBL24411073 | 0.93 | FYN (0.60) | CCNCCDK8FYNBRAFCSF1R | |
| SCHEMBL12056840 | 0.93 | CCNC (0.50) | CCNCCDK8FYNBRAFCSF1R | |
| SCHEMBL12056841 | 0.93 | FYN (0.60) | CCNCCDK8FYNBRAFCSF1R | |
| SCHEMBL18286638 | 0.93 | CCNC (0.50) | CCNCCDK8FYNBRAFCSF1R | |
| SCHEMBL12056823 | 0.93 | CCNC (0.50) | CCNCCDK8FYNBRAFCSF1R | |
| SCHEMBL12056824 | 0.93 | FYN (0.60) | CCNCCDK8FYNBRAFCSF1R | |
| SCHEMBL12056822 | 0.92 | CCNC (0.54) | CCNCCDK8FYNBRAFCSF1R | |
| SCHEMBL18286649 | 0.92 | CCNT1 (0.50) | CCNCCDK8FYNBRAFCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569917-B1 | PYRAZINE-BASED TUBULIN INHIBITORS | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2016-12-07 | — | — | EP | disclosed |