Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 3/20 | 0.57 |
| ▸ | RORA | P35398 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | IL2 | P60568 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16363178 | 0.89 | NR2E1 (0.56) | NR2E1RORATRPV1 | |
| SCHEMBL1828128 | 0.79 | P2RX1 (0.62) | TRPV1IL2 | |
| SCHEMBL1828980 | 0.79 | TRPV1 (0.57) | TRPV1 | |
| SCHEMBL8297621 | 0.78 | RXFP1 (0.57) | TRPV1IL2 | |
| SCHEMBL1828111 | 0.78 | STIM1 (0.55) | TRPV1IL2 | |
| SCHEMBL1828082 | 0.77 | IL2 (0.48) | TRPV1KDRBRAFMAPK14IL2 | |
| SCHEMBL1826042 | 0.76 | RXFP1 (0.59) | — | |
| SCHEMBL1825927 | 0.75 | IL2 (0.59) | TRPV1IL2 | |
| SCHEMBL1827094 | 0.74 | IL2 (0.50) | TRPV1IL2 | |
| SCHEMBL379808 | 0.74 | CYP3A4 (0.60) | NR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2319516-A1 | Compounds for treating inflammatory and autoimmune disorders | Synta Pharmaceuticals Corp. (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-2319516-A1 | Compounds for treating inflammatory and autoimmune disorders | Synta Pharmaceuticals Corp. (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-1651232-B1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2010-12-22 | — | — | EP | disclosed |