Efinaconazole

Efinaconazole

SCHEMBL18289604

C=C1CCN([C@@H](C)[C@](O)(Cn2cncn2)c2ccc(F)cc2F)CC1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 17/20 0.59
CYP2C9 P11712 13/20 0.59
CYP2C19 P33261 13/20 0.59
LMNA P02545 2/20 0.59
CYP2B6 P20813 1/20 0.59
CYP3A5 P20815 1/20 0.59
CYP3A7 P24462 1/20 0.59
MAPK1 P28482 1/20 0.59
CYP3A43 Q9HB55 1/20 0.59
CYP46A1 Q9Y6A2 1/20 0.59
CYP1A2 P05177 9/20 0.57
CYP2D6 P10635 9/20 0.57
KCNH2 Q12809 4/20 0.57
HSP90AA1 P07900 1/20 0.56
CYP19A1 P11511 1/20 0.56
CYP11B1 P15538 1/20 0.56
CYP11B2 P19099 1/20 0.56
ADRA1A P35348 1/20 0.56
CYP51A1 Q16850 1/20 0.56
ABCG2 Q9UNQ0 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Efinaconazole SCHEMBL8376515 1.00 CYP3A4 (0.59) CYP3A4CYP2C9CYP2C19LMNACYP2B6
Efinaconazole SCHEMBL300738 1.00 CYP3A4 (0.59) CYP3A4CYP2C9CYP2C19LMNACYP2B6
Efinaconazole SCHEMBL18289601 1.00 CYP3A4 (0.59) CYP3A4CYP2C9CYP2C19LMNACYP2B6
Efinaconazole SCHEMBL29858056 1.00 CYP3A4 (0.59) CYP3A4CYP2C9CYP2C19LMNACYP2B6
Efinaconazole SCHEMBL20259496 1.00 CYP3A4 (0.59) CYP3A4CYP2C9CYP2C19LMNACYP2B6
Efinaconazole SCHEMBL8375862 1.00 CYP3A4 (0.59) CYP3A4CYP2C9CYP2C19LMNACYP2B6
Efinaconazole SCHEMBL20017139 1.00 CYP3A4 (0.59) CYP3A4CYP2C9CYP2C19LMNACYP2B6
SCHEMBL8375955 0.94 CYP3A4 (0.57) CYP3A4CYP2C9CYP2C19LMNACYP2B6
SCHEMBL8375839 0.94 CYP3A4 (0.57) CYP3A4CYP2C9CYP2C19LMNACYP2B6
SCHEMBL8375117 0.94 CYP3A4 (0.57) CYP3A4CYP2C9CYP2C19LMNACYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3628668-B1 PRODUCTION AND PURIFICATION METHODS FOR EFINACONAZOLE KAKEN PHARMA CO LTD (JP) 2023-02-22 EP disclosed
US-10829475-B2 Production and purification methods for efinaconazole KAKEN PHARMACEUTICAL CO., LTD. (JP) 2020-11-10 US disclosed
US-20200181110-A1 PRODUCTION AND PURIFICATION METHODS FOR EFINACONAZOLE KAKEN PHARMA CO LTD (JP) 2020-06-11 US disclosed
US-20190292166-A1 PRODUCTION AND PURIFICATION METHODS FOR EFINACONAZOLE KAKEN PHARMACEUTICAL CO., LTD. (JP) 2019-09-26 US disclosed
US-20180162833-A1 PROCESS FOR THE PREPARATION OF EFINACONAZOLE GLENMARK LIFE SCIENCES LIMITED (IN) 2018-06-14 US disclosed
US-20180162833-A1 PROCESS FOR THE PREPARATION OF EFINACONAZOLE GLENMARK LIFE SCIENCES LIMITED (IN) 2018-06-14 US disclosed
WO-2016193917-A1 PROCESS FOR THE PREPARATION OF EFINACONAZOLE GLENMARK PHARMACEUTICALS LIMITED (IN) 2016-12-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180162833-A1 PROCESS FOR THE PREPARATION OF EFINACONAZOLE CYP3A43, CYP3A5, CYP51A1 CYP3A4 4/4885CYP2C9 13/4885CYP2C19 12/4885
US-20190292166-A1 PRODUCTION AND PURIFICATION METHODS FOR EFINACONAZOLE CYP4B1, ERG28, CYP4F3 CYP3A4 6/4885CYP2C9 50/4885CYP2C19 44/4885
US-20200181110-A1 PRODUCTION AND PURIFICATION METHODS FOR EFINACONAZOLE CYP4B1, ERG28, CYP4F3 CYP3A4 6/4885CYP2C9 50/4885CYP2C19 44/4885
US-10829475-B2 Production and purification methods for efinaconazole CYP4B1, ERG28, CYP4F3 CYP3A4 6/4885CYP2C9 50/4885CYP2C19 44/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.