Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 4/20 | 0.36 |
| ▸ | BIRC2 | Q13490 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.31 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.31 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.31 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.31 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.31 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.31 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.31 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.31 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1829105 | 1.00 | XIAP (0.36) | XIAPBIRC2LMNAPMP22NPSR1 | |
| SCHEMBL1829103 | 1.00 | XIAP (0.36) | XIAPBIRC2LMNAPMP22NPSR1 | |
| SCHEMBL12713649 | 0.86 | RORC (0.36) | XIAPBIRC2 | |
| SCHEMBL1612501 | 0.86 | RORC (0.36) | XIAPBIRC2 | |
| SCHEMBL1612502 | 0.86 | RORC (0.36) | XIAPBIRC2 | |
| SCHEMBL1612498 | 0.86 | RORC (0.36) | XIAPBIRC2 | |
| SCHEMBL15401238 | 0.77 | NOTUM (0.47) | XIAPBIRC2LMNAPMP22NPSR1 | |
| SCHEMBL13732568 | 0.74 | XIAP (0.57) | XIAPBIRC2LMNAPMP22NPSR1 | |
| SCHEMBL1830230 | 0.72 | XIAP (0.43) | XIAPBIRC2LMNAPMP22NPSR1 | |
| SCHEMBL1612202 | 0.71 | RORC (0.38) | XIAPBIRC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |