Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18290590 | 0.85 | — | — | |
| SCHEMBL14006361 | 0.63 | NPSR1 (0.34) | — | |
| SCHEMBL19199404 | 0.62 | PDE4D (0.41) | — | |
| SCHEMBL19773320 | 0.58 | P2RX7 (0.37) | — | |
| SCHEMBL5318087 | 0.54 | HPGD (0.36) | — | |
| Methoxymethane SCHEMBL6557527 | 0.53 | TSHR (0.63) | — | |
| Methoxymethane SCHEMBL6774591 | 0.53 | TSHR (0.44) | — | |
| SCHEMBL8600029 | 0.52 | TSHR (0.71) | — | |
| SCHEMBL15167 | 0.52 | — | — | |
| SCHEMBL439119 | 0.52 | TSHR (0.71) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016191935-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016196071-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | WO | disclosed |