Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21246245 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1KCNH2SLC22A2SLC22A1 | |
| SCHEMBL10449753 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1KCNH2SLC22A2SLC22A1 | |
| SCHEMBL11537649 | 0.79 | KCNH2 (0.55) | SMN1; SMN2L3MBTL1KCNH2SLC22A2SLC22A1 | |
| SCHEMBL6888537 | 0.76 | CHRM2 (0.36) | SMN1; SMN2L3MBTL1KCNH2SLC22A2SLC22A1 | |
| SCHEMBL15693459 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1KCNH2SLC22A2SLC22A1 | |
| SCHEMBL21191856 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1KCNH2SLC22A2SLC22A1 | |
| SCHEMBL18427298 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1KCNH2SLC22A2SLC22A1 | |
| SCHEMBL14434214 | 0.73 | — | — | |
| SCHEMBL6996539 | 0.73 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1TDP1GAAMEN1 | |
| SCHEMBL13342069 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1BLMALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729772-B1 | HETEROARYL PIPERIDINE GLYCINE TRANSPORTER INHIBITORS | MERCK SHARP & DOHME (US) | 2016-12-07 | — | — | EP | disclosed |