Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28857028 | 0.85 | RET (0.47) | PIK3CDTBK1BTKPIK3R1JAK3 | |
| SCHEMBL22346924 | 0.80 | JAK3 (0.52) | PIK3CDBTKPIK3R1JAK3LCK | |
| SCHEMBL22346927 | 0.80 | JAK3 (0.52) | PIK3CDBTKPIK3R1JAK3LCK | |
| SCHEMBL18296152 | 0.80 | LCK (0.49) | PIK3CDBTKJAK3LCKALK | |
| SCHEMBL28856906 | 0.79 | JAK3 (0.47) | PIK3CDBTKPIK3R1JAK3LCK | |
| SCHEMBL28856908 | 0.79 | JAK3 (0.47) | PIK3CDBTKPIK3R1JAK3LCK | |
| SCHEMBL23081221 | 0.79 | JAK3 (0.45) | PIK3CDTBK1BTKJAK2JAK1 | |
| SCHEMBL25604893 | 0.78 | JAK3 (0.43) | PIK3CDBTKJAK3LCK | |
| SCHEMBL23080834 | 0.78 | JAK3 (0.48) | PIK3CDTBK1BTKJAK2JAK1 | |
| SCHEMBL18284083 | 0.77 | PIK3CD (0.42) | PIK3CDJAK2JAK1JAK3IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |