Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CDK7 | P50613 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21855327 | 0.87 | JAK3 (0.45) | LCKBTKALKEGFRJAK3 | |
| SCHEMBL21855200 | 0.85 | JAK3 (0.47) | LCKBTKALKEGFRJAK3 | |
| SCHEMBL21946882 | 0.82 | JAK3 (0.60) | LCKBTKEGFRJAK3CCNA2 | |
| SCHEMBL21946316 | 0.82 | JAK3 (0.60) | LCKBTKEGFRJAK3CCNA2 | |
| SCHEMBL31039916 | 0.82 | JAK3 (0.60) | LCKBTKEGFRJAK3CCNA2 | |
| SCHEMBL24927487 | 0.82 | JAK3 (0.60) | LCKBTKEGFRJAK3CCNA2 | |
| SCHEMBL25604893 | 0.81 | JAK3 (0.43) | LCKBTKEGFRJAK3PIK3CD | |
| SCHEMBL18296104 | 0.80 | PIK3CD (0.50) | LCKBTKALKJAK3PIK3CD | |
| SCHEMBL21946788 | 0.79 | JAK3 (0.50) | LCKBTKEGFRJAK3AURKA | |
| SCHEMBL18296155 | 0.79 | LCK (0.73) | LCKBTKALKEGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016196776-A2 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS LLC. (US) | 2016-12-08 | — | — | WO | disclosed |