Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1829774 | 0.85 | HRH2 (0.41) | HRH2HRH1KDM4EMAPK14GRM2 | |
| SCHEMBL1829684 | 0.78 | HRH2 (0.45) | HRH2HRH1HSD17B10MAPK14GRM2 | |
| SCHEMBL1828357 | 0.74 | GRM2 (0.42) | HRH2HRH1MAPK14GRM2FNTA | |
| SCHEMBL7229011 | 0.74 | HRH2 (0.47) | HRH2HRH1KDM4EALDH1A1HPGD | |
| SCHEMBL1829979 | 0.72 | HRH2 (0.40) | HRH2HRH1MAPK14GRM2EGLN1 | |
| SCHEMBL2029562 | 0.69 | PTGS1 (0.46) | HRH2HRH1KDM4EALDH1A1HPGD | |
| SCHEMBL247807 | 0.69 | PLAU (0.42) | SMN1; SMN2APPCYP2C19 | |
| SCHEMBL1828903 | 0.69 | GRM2 (0.38) | HRH2HRH1MAPK14GRM2FNTA | |
| SCHEMBL247116 | 0.68 | PLAU (0.38) | SMN1; SMN2ALDH1A1APPCYP2C19 | |
| SCHEMBL1828937 | 0.67 | HRH2 (0.40) | HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315590-A1 | PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE | N30 Pharmaceuticals, LLC (US) | 2011-05-04 | — | — | EP | disclosed |
| WO-2010019909-A1 | PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE | N30 PHARMACEUTICALS, LLC (US) | 2010-02-18 | — | — | WO | disclosed |