SCHEMBL1829684

SCHEMBL1829684

COc1ccc(-c2ccn(CCCC(=O)O)c2-c2ccc(C#N)cc2C)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH2 P25021 1/20 0.45
HRH1 P35367 1/20 0.45
GRM2 Q14416 1/20 0.40
MMP2 P08253 1/20 0.39
GABRP O00591 1/20 0.39
GABRD O14764 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
GABRA1 P14867 1/20 0.39
ALOX15 P16050 1/20 0.39
GABRB1 P18505 1/20 0.39
GABRG2 P18507 1/20 0.39
GABRB3 P28472 1/20 0.39
GABRA5 P31644 1/20 0.39
CYP2C19 P33261 1/20 0.39
GABRA3 P34903 1/20 0.39
GABRA2 P47869 1/20 0.39
GABRB2 P47870 1/20 0.39
GABRA4 P48169 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1828357 0.84 GRM2 (0.42) HRH2HRH1GRM2GABRA1GABRG2
SCHEMBL244137 0.83 PDE4B (0.41) GABRPGABRDCYP1A2CYP2D6CYP2C9
SCHEMBL1828937 0.83 HRH2 (0.40) HRH2HRH1MMP2FFAR1
SCHEMBL1829979 0.80 HRH2 (0.40) HRH2HRH1GRM2MAPK14HTR1A
SCHEMBL1829774 0.79 HRH2 (0.41) HRH2HRH1GRM2MAPK14KEAP1
SCHEMBL1829683 0.78 HRH2 (0.44) HRH2HRH1GRM2CYP2C19HSD17B10
SCHEMBL245423 0.77 CASP3 (0.45) CASP3SENP8SENP7SENP6MAPKAPK2
SCHEMBL1828903 0.77 GRM2 (0.38) HRH2HRH1GRM2MAPK14FNTA
SCHEMBL1903906 0.76 HRH2 (0.37) HRH2HRH1GRM2FNTAFNTB
SCHEMBL1828289 0.76 ADH5 (0.51) CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2315590-A1 PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE N30 Pharmaceuticals, LLC (US) 2011-05-04 EP disclosed
WO-2010019909-A1 PYRROLE INHIBITORS OF S-NITROSOGLUTATHIONE REDUCTASE N30 PHARMACEUTICALS, LLC (US) 2010-02-18 WO disclosed