Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 7/20 | 0.81 |
| ▸ | CA1 | P00915 | 2/20 | 0.81 |
| ▸ | CA4 | P22748 | 2/20 | 0.81 |
| ▸ | CA6 | P23280 | 2/20 | 0.81 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.81 |
| ▸ | CA2 | P00918 | 1/20 | 0.81 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.81 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.81 |
| ▸ | ITGAL | P20701 | 1/20 | 0.81 |
| ▸ | ADK | P55263 | 1/20 | 0.81 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indole SCHEMBL2473213 | 1.00 | AHR (0.81) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL28120363 | 1.00 | AHR (0.81) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL27892340 | 0.98 | AHR (0.77) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL28008314 | 0.92 | AHR (0.68) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL30463845 | 0.90 | — | — | |
| Indole SCHEMBL29352896 | 0.90 | — | — | |
| Indole SCHEMBL30250492 | 0.90 | — | — | |
| Indole SCHEMBL1160186 | 0.90 | AHR (1.00) | AHRCA1CA4CA6TRPA1 | |
| Indole SCHEMBL698 | 0.90 | — | — | |
| Indole SCHEMBL28071644 | 0.90 | AHR (1.00) | AHRCA1CA4CA6TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711486-B1 | BIS-INDOLE PYRROLES USEFUL AS ANTIMICROBIAL AGENTS | NEREUS PHARMACEUTICALS INC (US) | 2011-05-11 | — | — | EP | disclosed |
| US-7375129-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-20070149601-A1 | Bis-indole pyrroles useful as antimicrobials agents | PRIVATE LIFE BIOMED AG (DE) | 2007-06-28 | — | — | US | disclosed |
| US-7166634-B2 | Bis-indole pyrroles useful as antimicrobials agents | NEREUS PHARMACEUTICALS, INC. (US) | 2007-01-23 | — | — | US | disclosed |
| EP-1711486-A2 | BIS-INDOLE PYRROLES USEFUL AS ANTIMICROBIALS AGENTS | Nereus Pharmaceuticals, Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| US-20050267192-A1 | Bis-indole pyrroles useful as antimicrobials agents | HBM BIOCAPITAL (EUR) L.P. (KY) | 2005-12-01 | — | — | US | disclosed |
| WO-2005070922-A2 | BIS-INDOLE PYRROLES USEFUL AS ANTIMICROBIALS AGENTS | NEREUS PHARMACEUTICALS, INC. (US) | 2005-08-04 | — | — | WO | disclosed |
| EP-0612742-A1 | A physiologically active bisindole-pyrrole derivative | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1994-08-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149601-A1 | Bis-indole pyrroles useful as antimicrobials agents | IDO1, IDO2, TPH1 | AHR 100/4885CA1 4698/4885CA4 4687/4885 |
| US-20050267192-A1 | Bis-indole pyrroles useful as antimicrobials agents | IDO1, IDO2, TPH1 | AHR 100/4885CA1 4698/4885CA4 4687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.