Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4174631 | 0.79 | MAPT (0.49) | MAPTALDH1A1HTTLMNAMEN1 | |
| SCHEMBL31276651 | 0.79 | MAPT (0.49) | MAPTALDH1A1HTTLMNAMEN1 | |
| SCHEMBL4176261 | 0.79 | MAPT (0.49) | MAPTALDH1A1HTTLMNAMEN1 | |
| SCHEMBL17320636 | 0.79 | MAPT (0.49) | MAPTALDH1A1HTTLMNAMEN1 | |
| SCHEMBL3859982 | 0.79 | MAPT (0.49) | MAPTALDH1A1HTTLMNAMEN1 | |
| SCHEMBL31009464 | 0.79 | MAPT (0.45) | MAPTALDH1A1HTTLMNAMEN1 | |
| SCHEMBL1515807 | 0.77 | MAPT (0.46) | MAPTALDH1A1HTTLMNAMEN1 | |
| SCHEMBL31009404 | 0.76 | MAPT (0.35) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL4182016 | 0.76 | VCAM1 (0.51) | MAPTALDH1A1HTTMEN1KMT2A | |
| SCHEMBL31009333 | 0.76 | MAPT (0.45) | MAPTALDH1A1HTTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016199943-A1 | HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-15 | — | — | WO | disclosed |
| WO-2016199943-A1 | HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-15 | — | — | WO | disclosed |