Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP5 | P45974 | 1/20 | 0.48 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7457457 | 0.85 | FDPS (0.42) | USP5FDPSHDAC1HDAC6DNMT3B | |
| SCHEMBL7455152 | 0.81 | FDPS (0.42) | USP5FDPSHDAC1HDAC6DNMT3B | |
| SCHEMBL30539287 | 0.80 | ADORA2A (0.47) | FDPSHDAC1HDAC6HCAR3ALDH1A1 | |
| SCHEMBL754943 | 0.80 | ADORA2A (0.47) | FDPSHDAC1HDAC6HCAR3ALDH1A1 | |
| SCHEMBL5025564 | 0.77 | FDPS (0.41) | FDPSHDAC1HDAC6TSHRIRAK4 | |
| SCHEMBL7446654 | 0.76 | FDPS (0.42) | FDPSHDAC1HDAC6DNMT3BHCAR3 | |
| SCHEMBL28187328 | 0.75 | FDPS (0.41) | USP5FDPSHDAC1HDAC6DNMT3B | |
| SCHEMBL7451329 | 0.75 | FDPS (0.41) | FDPSHDAC1HDAC6DNMT3BTSHR | |
| SCHEMBL22571187 | 0.74 | ADORA2A (0.53) | FDPSHDAC1HDAC6TSHRKDM4E | |
| SCHEMBL28038040 | 0.74 | FDPS (0.43) | FDPSHDAC1HDAC6DNMT3BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493895-A1 | N-CONTAINING HETEROARYL DERIVATIVES AS JAK3 KINASE INHIBITORS | Palau Pharma, S.A. (ES) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051452-A1 | N-CONTAINING HETEROARYL DERIVATIVES AS JAK3 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2011-05-05 | — | — | WO | disclosed |