Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 1/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.37 |
| ▸ | ITK | Q08881 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.37 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23130729 | 0.71 | HTT (0.47) | HTTTP53ALOX12HPGDHCAR3 | |
| SCHEMBL27858982 | 0.70 | PTPN2 (0.52) | ATM | |
| SCHEMBL13027800 | 0.68 | MEN1 (0.54) | KDM4COPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL24460791 | 0.68 | KLKB1 (0.45) | TP53KDM4CKDM4EASPHKDM8 | |
| SCHEMBL4771303 | 0.67 | HTT (1.00) | HTTTP53ALOX12KDM4E | |
| SCHEMBL24966874 | 0.67 | TP53 (0.51) | TP53ALOX12KDM4EHPGDCYP19A1 | |
| SCHEMBL24966930 | 0.67 | TP53 (0.51) | TP53ALOX12KDM4EHPGDCYP19A1 | |
| SCHEMBL23234141 | 0.67 | TP53 (0.51) | TP53ALOX12KDM4EHPGDCYP19A1 | |
| SCHEMBL795210 | 0.67 | HPGD (0.68) | HTTHPGDHCAR3CYP19A1 | |
| SCHEMBL3491684 | 0.67 | ALDH1A1 (0.45) | KDM4CKDM4EASPHKDM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951185-B1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | APTINYX INC (US) | 2016-12-21 | — | — | EP | disclosed |