Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 18/20 | 0.53 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14617027 | 0.93 | DGAT1 (0.56) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL180991 | 0.93 | DGAT1 (0.56) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL13664072 | 0.93 | DGAT1 (0.56) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL180965 | 0.91 | DGAT1 (0.56) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL180681 | 0.91 | DGAT1 (0.48) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL181139 | 0.86 | DGAT1 (0.49) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL180414 | 0.86 | DGAT1 (0.51) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL15445165 | 0.80 | DHODH (0.46) | DGAT1SOAT1CCNT1CDK9 | |
| SCHEMBL180697 | 0.78 | DGAT1 (0.66) | DGAT1SOAT1 | |
| SCHEMBL14617029 | 0.78 | DGAT1 (0.66) | DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402318-A1 | DGAT inhibitors | Novartis AG (CH) | 2012-01-04 | — | — | EP | disclosed |