Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | MME | P08473 | 5/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 6/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38173 | 0.92 | FOLH1 (0.51) | NAALAD2MEN1KMT2AL3MBTL1FOLH1 | |
| SCHEMBL38174 | 0.92 | FOLH1 (0.51) | NAALAD2MEN1KMT2AL3MBTL1FOLH1 | |
| Tyrosine SCHEMBL18045291 | 0.84 | SLC7A5 (0.65) | NAALAD2MEN1KMT2AL3MBTL1FOLH1 | |
| Tyrosine SCHEMBL18045293 | 0.84 | SLC7A5 (0.65) | NAALAD2MEN1KMT2AL3MBTL1FOLH1 | |
| SCHEMBL8642868 | 0.82 | CA2 (0.44) | NAALAD2MEN1KMT2AL3MBTL1FOLH1 | |
| Tyrosine SCHEMBL28280041 | 0.81 | SLC7A5 (0.60) | MMESLC7A5ACE | |
| Tyrosine SCHEMBL28280042 | 0.81 | SLC7A5 (0.60) | MMESLC7A5ACE | |
| SCHEMBL93588 | 0.79 | CPA1 (0.54) | NAALAD2L3MBTL1MMECPA1 | |
| SCHEMBL414333 | 0.79 | CPA1 (0.54) | NAALAD2L3MBTL1MMECPA1 | |
| SCHEMBL93589 | 0.79 | CPA1 (0.54) | NAALAD2L3MBTL1MMECPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108135964-B | Glutathione formulations and methods of use | 分子防御公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-108135964-A | Glutathione preparation and application method | 分子防御公司 | 2018-06-08 | — | — | CN | disclosed |
| EP-3310374-A1 | GLUTATHIONE FORMULATION AND METHOD OF USE | Molecular Defenses Corporation (US) | 2018-04-25 | — | — | EP | disclosed |
| US-9901611-B2 | Glutathione formulation and method of use | Molecular Defenses Corporation (US) | 2018-02-27 | — | — | US | disclosed |
| US-20160367620-A1 | GLUTATHIONE | DEMOPOULOS HARRY B (US) | 2016-12-22 | — | — | US | disclosed |
| US-20160367621-A1 | GLUTATHIONE FORMULATION AND METHOD OF USE | Molecular Defenses Corporation | 2016-12-22 | — | — | US | disclosed |
| WO-2016205804-A1 | GLUTATHIONE FORMULATION AND METHOD OF USE | Molecular Defenses Corporation (US) | 2016-12-22 | — | — | WO | disclosed |