SCHEMBL1831746

SCHEMBL1831746

Cc1ccc(NC(=O)c2cn(Cc3ccc(N)c(C)c3)nc2C(F)(F)C(F)(F)F)cc1

nearest known ligand 0.48

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 16/20 0.48
KLK1 P06870 2/20 0.45
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
LMNA P02545 1/20 0.42
POLB P06746 1/20 0.42
NR1H4 Q96RI1 1/20 0.42
PTGDR2 Q9Y5Y4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2161268 0.94 KLKB1 (0.44) KLKB1KLK1LMNAPOLBNR1H4
SCHEMBL1832795 0.93 PTGDR2 (0.45) KLKB1KLK1LMNAPOLBNR1H4
SCHEMBL2161320 0.93 LMNA (0.52) KLKB1KLK1MEN1KMT2ALMNA
SCHEMBL1833717 0.92 KLKB1 (0.45) KLKB1KLK1MEN1KMT2ALMNA
SCHEMBL1833706 0.91 P2RX1 (0.45) KLKB1KLK1NR1H4PTGDR2
SCHEMBL2161265 0.90 KLKB1 (0.44) KLKB1KLK1LMNAPOLBNR1H4
SCHEMBL1837274 0.88 LCK (0.50) MEN1KMT2ALMNANR1H4PTGDR2
SCHEMBL2161860 0.85 KLKB1 (0.48) KLKB1KLK1LMNAPOLB
SCHEMBL1834168 0.84 KLKB1 (0.49) KLKB1KLK1
SCHEMBL1838151 0.83 KLKB1 (0.41) KLKB1KLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110184188-A1 Insecticidal Benzenedicarboxamide Derivative BAYER CROPSCIENCE AG (DE) 2011-07-28 US disclosed
EP-2318374-A2 INSECTICIDAL BENZENEDICARBOXAMIDE DERIVATIVE Bayer CropScience AG (DE) 2011-05-11 EP disclosed
WO-2010012442-A2 INSECTICIDAL BENZENEDICARBOXAMIDE DERIVATIVE BAYER CROPSCIENCE AG (DE) 2010-02-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110184188-A1 Insecticidal Benzenedicarboxamide Derivative DDT, BRD9, BCL2A1 KLKB1 4858/4885KLK1 4844/4885MEN1 4180/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.