Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | GCKR | Q14397 | 8/20 | 0.39 |
| ▸ | GCK | P35557 | 6/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17181 | 1.00 | HSD11B1 (0.43) | HSD11B1RAD52GCKRGCKHTR2A | |
| SCHEMBL12078657 | 1.00 | HSD11B1 (0.43) | HSD11B1RAD52GCKRGCKHTR2A | |
| Hydrochloric Acid SCHEMBL16799 | 0.99 | RAD52 (0.44) | HSD11B1RAD52GCKRGCKHTR2A | |
| Hydrochloric Acid SCHEMBL29627 | 0.99 | RAD52 (0.44) | HSD11B1RAD52GCKRGCKHTR2A | |
| SCHEMBL18202 | 0.88 | GCKR (0.47) | RAD52GCKRGCKHTR2C | |
| SCHEMBL19294 | 0.88 | GCKR (0.47) | RAD52GCKRGCKHTR2C | |
| Hydrochloric Acid SCHEMBL12078152 | 0.86 | GCKR (0.46) | RAD52GCKRGCKHTR2C | |
| Hydrochloric Acid SCHEMBL16351 | 0.86 | GCKR (0.46) | RAD52GCKRGCKHTR2C | |
| Hydrochloric Acid SCHEMBL16350 | 0.86 | GCKR (0.46) | RAD52GCKRGCKHTR2C | |
| Hydrochloric Acid SCHEMBL12078148 | 0.86 | GCKR (0.46) | RAD52GCKRGCKHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |