Sugi Predict

Sugi Predict / Compounds / SCHEMBL18318138

SCHEMBL18318138

SCHEMBL18318138

O=C(c1cccc(-c2ncc[nH]2)c1)N1CCC(Oc2ccc(-c3cnc4ccccc4c3)cc2)CC1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HCRTR2 O43614 1/20 0.51
▸ PIK3CA P42336 3/20 0.47
▸ PIK3CD O00329 2/20 0.47
▸ MTOR P42345 1/20 0.47
▸ KCNH2 Q12809 1/20 0.47
▸ PIK3CB P42338 1/20 0.47
▸ PIK3CG P48736 1/20 0.47
▸ HTR2B P41595 7/20 0.46
▸ FASN P49327 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ MKNK2 Q9HBH9 3/20 0.43
▸ MKNK1 Q9BUB5 2/20 0.43
▸ HCRTR1 O43613 1/20 0.43
▸ MAP4K4 O95819 2/20 0.42
▸ CSNK1G2 P78368 2/20 0.42
▸ CLK4 Q9HAZ1 2/20 0.42
▸ MAP4K5 Q9Y4K4 2/20 0.42
▸ PLK4 O00444 1/20 0.42
▸ JAK2 O60674 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28565653 0.99 HCRTR2 (0.51) HCRTR2PIK3CAPIK3CDMTORKCNH2
SCHEMBL18318224 0.90 ATR (0.49) PIK3CAPIK3CDMTORKCNH2PIK3CB
Hydrochloric Acid SCHEMBL28554599 0.89 ATR (0.48) PIK3CAPIK3CDMTORKCNH2PIK3CB
SCHEMBL18318485 0.86 FASN (0.58) PIK3CAPIK3CDMTORKCNH2PIK3CB
Hydrochloric Acid SCHEMBL28559154 0.85 FASN (0.57) PIK3CAPIK3CDMTORKCNH2PIK3CB
SCHEMBL18318598 0.78 FASN (0.52) PIK3CAPIK3CDMTORFASN
SCHEMBL18319233 0.78 CHEK2 (0.52) PIK3CAPIK3CDPIK3CBPIK3CGFASN
SCHEMBL30497889 0.78 CHEK2 (0.52) PIK3CAPIK3CDPIK3CBPIK3CGFASN
SCHEMBL18318111 0.77 FASN (0.46) PIK3CAPIK3CDKCNH2FASNALDH1A1
Hydrochloric Acid SCHEMBL18318805 0.77 FASN (0.51) PIK3CAPIK3CDMTORFASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US claimed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US claimed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN claimed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP claimed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US claimed
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US disclosed
EP-3310441-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES Cephalon, Inc. (US) 2018-04-25 — — EP disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A HCRTR2 3462/4885PIK3CA 752/4885PIK3CD 990/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A HCRTR2 3462/4885PIK3CA 752/4885PIK3CD 990/4885
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A HCRTR2 3462/4885PIK3CA 752/4885PIK3CD 990/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A HCRTR2 3462/4885PIK3CA 752/4885PIK3CD 990/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A HCRTR2 3462/4885PIK3CA 752/4885PIK3CD 990/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A HCRTR2 3462/4885PIK3CA 752/4885PIK3CD 990/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.