Sugi Predict

Sugi Predict / Compounds / SCHEMBL18318280

SCHEMBL18318280

SCHEMBL18318280

CCC(=O)N1CCC(Oc2ccc(-c3cnc4ccccc4c3)cc2)C1

nearest known ligand 0.63

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 16/20 0.63
▸ PIK3CA P42336 9/20 0.63
▸ PIK3CG P48736 6/20 0.54
▸ PIK3CB P42338 6/20 0.54
▸ FASN P49327 2/20 0.49
▸ MTOR P42345 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18319424 1.00 PIK3CD (0.63) PIK3CDPIK3CAPIK3CGPIK3CBFASN
SCHEMBL18318279 1.00 PIK3CD (0.63) PIK3CDPIK3CAPIK3CGPIK3CBFASN
SCHEMBL18318656 0.94 PIK3CA (0.56) PIK3CDPIK3CAPIK3CGPIK3CBFASN
SCHEMBL18318152 0.92 PIK3CA (0.53) PIK3CDPIK3CAPIK3CGPIK3CBFASN
SCHEMBL18318446 0.85 PIK3CA (0.46) PIK3CDPIK3CAFASNMTOR
SCHEMBL18318598 0.85 FASN (0.52) PIK3CDPIK3CAFASNMTOR
SCHEMBL30497889 0.85 CHEK2 (0.52) PIK3CDPIK3CAPIK3CGPIK3CBFASN
SCHEMBL18319233 0.85 CHEK2 (0.52) PIK3CDPIK3CAPIK3CGPIK3CBFASN
SCHEMBL18327016 0.84 KMT2A (0.53) PIK3CDPIK3CA
SCHEMBL18318089 0.84 PIK3CA (0.54) PIK3CDPIK3CAPIK3CGPIK3CBFASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US claimed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US claimed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN claimed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP claimed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US claimed
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US disclosed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN disclosed
US-10851057-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2020-12-01 — — US disclosed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP disclosed
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2019-05-23 — — US disclosed
US-10221135-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2019-03-05 — — US disclosed
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2018-06-28 — — US disclosed
EP-3310441-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES Cephalon, Inc. (US) 2018-04-25 — — EP disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A PIK3CD 990/4885PIK3CA 752/4885PIK3CG 1230/4885
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A PIK3CD 990/4885PIK3CA 752/4885PIK3CG 1230/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A PIK3CD 990/4885PIK3CA 752/4885PIK3CG 1230/4885
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A PIK3CD 990/4885PIK3CA 752/4885PIK3CG 1230/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A PIK3CD 990/4885PIK3CA 752/4885PIK3CG 1230/4885
US-10221135-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A PIK3CD 990/4885PIK3CA 752/4885PIK3CG 1230/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A PIK3CD 990/4885PIK3CA 752/4885PIK3CG 1230/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A PIK3CD 990/4885PIK3CA 752/4885PIK3CG 1230/4885
US-10851057-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A PIK3CD 990/4885PIK3CA 752/4885PIK3CG 1230/4885
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A PIK3CD 1008/4885PIK3CA 776/4885PIK3CG 1291/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.