Sugi Predict

Sugi Predict / Compounds / SCHEMBL18318296

SCHEMBL18318296

SCHEMBL18318296

O=C(C1CC1)N1CCC(Oc2ncc(-c3cnc4ccccc4c3)cn2)CC1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ FASN P49327 6/20 0.49
▸ PIK3CD O00329 2/20 0.45
▸ PIK3CA P42336 2/20 0.45
▸ NAMPT P43490 1/20 0.43
▸ MTOR P42345 1/20 0.42
▸ HTR2B P41595 1/20 0.41
▸ HMOX1 P09601 1/20 0.41
▸ MAP4K4 O95819 1/20 0.41
▸ CSNK1G2 P78368 1/20 0.41
▸ CLK4 Q9HAZ1 1/20 0.41
▸ MKNK2 Q9HBH9 1/20 0.41
▸ MAP4K5 Q9Y4K4 1/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ TP53 P04637 1/20 0.41
▸ MAPT P10636 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ FAAH O00519 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18318486 0.88 PIK3CA (0.51) FASNPIK3CDPIK3CAMTOR
SCHEMBL18318598 0.88 FASN (0.52) FASNPIK3CDPIK3CANAMPTMTOR
Hydrochloric Acid SCHEMBL18318805 0.87 FASN (0.51) FASNPIK3CDPIK3CANAMPTMTOR
SCHEMBL18318629 0.87 NAMPT (0.53) FASNPIK3CDPIK3CANAMPTMTOR
SCHEMBL18318756 0.86 PIK3CA (0.51) FASNPIK3CDPIK3CANAMPTMTOR
Hydrochloric Acid SCHEMBL28566713 0.86 NAMPT (0.52) FASNPIK3CDPIK3CANAMPTMTOR
SCHEMBL18318270 0.86 FASN (0.47) FASNPIK3CDPIK3CAMAP4K4CSNK1G2
SCHEMBL18318397 0.84 NAMPT (0.51) FASNPIK3CDPIK3CANAMPTMAPT
SCHEMBL18319312 0.84 FASN (0.49) FASNPIK3CDPIK3CANAMPTMAPT
SCHEMBL18318213 0.83 FASN (0.47) FASNPIK3CDPIK3CAMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US claimed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US claimed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN claimed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP claimed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US claimed
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US disclosed
EP-3310441-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES Cephalon, Inc. (US) 2018-04-25 — — EP disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A FASN 1/4885PIK3CD 990/4885PIK3CA 752/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A FASN 1/4885PIK3CD 990/4885PIK3CA 752/4885
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A FASN 1/4885PIK3CD 990/4885PIK3CA 752/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A FASN 1/4885PIK3CD 990/4885PIK3CA 752/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A FASN 1/4885PIK3CD 990/4885PIK3CA 752/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A FASN 1/4885PIK3CD 990/4885PIK3CA 752/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.