Sugi Predict

Sugi Predict / Compounds / SCHEMBL18318756

SCHEMBL18318756

SCHEMBL18318756

CC(C)C(=O)N1CCC(Oc2ncc(-c3cnc4ccccc4c3)cn2)CC1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PIK3CA P42336 6/20 0.51
▸ MTOR P42345 5/20 0.51
▸ NAMPT P43490 1/20 0.46
▸ HMOX1 P09601 1/20 0.44
▸ MAP4K4 O95819 1/20 0.41
▸ CSNK1G2 P78368 1/20 0.41
▸ CLK4 Q9HAZ1 1/20 0.41
▸ MKNK2 Q9HBH9 1/20 0.41
▸ MAP4K5 Q9Y4K4 1/20 0.41
▸ FASN P49327 2/20 0.41
▸ AKR1C3 P42330 1/20 0.41
▸ AKR1C2 P52895 1/20 0.41
▸ SMO Q99835 1/20 0.40
▸ CHRNB1 P11230 1/20 0.40
▸ CHRNB2 P17787 1/20 0.40
▸ CHRNB4 P30926 1/20 0.40
▸ CHRNA3 P32297 1/20 0.40
▸ CHRNB3 Q05901 1/20 0.40
▸ DYRK1A Q13627 1/20 0.39
▸ PIK3CD O00329 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18318670 0.89 PIK3CA (0.51) PIK3CAMTORNAMPTFASNCHRNB1
Hydrochloric Acid SCHEMBL28554846 0.88 PIK3CA (0.50) PIK3CAMTORNAMPTFASNCHRNB1
SCHEMBL18318211 0.88 NAMPT (0.55) PIK3CAMTORNAMPTFASNPIK3CD
Hydrochloric Acid SCHEMBL28559841 0.87 NAMPT (0.55) PIK3CAMTORNAMPTFASNPIK3CD
SCHEMBL18318296 0.86 FASN (0.49) PIK3CAMTORNAMPTHMOX1MAP4K4
SCHEMBL18318486 0.85 PIK3CA (0.51) PIK3CAMTORFASNDYRK1APIK3CD
SCHEMBL18318622 0.85 PIK3CA (0.50) PIK3CAMTORNAMPTMAP4K4CSNK1G2
SCHEMBL18318246 0.84 PIK3CA (0.49) PIK3CAMTORNAMPTFASNSMO
SCHEMBL18318707 0.84 PIK3CA (0.47) PIK3CAMTORNAMPTMAP4K4CSNK1G2
SCHEMBL18318194 0.84 PIK3CA (0.47) PIK3CAMTORNAMPTMAP4K4CSNK1G2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US claimed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US claimed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN claimed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP claimed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US claimed
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US disclosed
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2018-06-28 — — US disclosed
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2018-06-28 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A PIK3CA 752/4885MTOR 2038/4885NAMPT 491/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A PIK3CA 752/4885MTOR 2038/4885NAMPT 491/4885
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A PIK3CA 752/4885MTOR 2038/4885NAMPT 491/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A PIK3CA 752/4885MTOR 2038/4885NAMPT 491/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A PIK3CA 752/4885MTOR 2038/4885NAMPT 491/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A PIK3CA 752/4885MTOR 2038/4885NAMPT 491/4885
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A PIK3CA 776/4885MTOR 2043/4885NAMPT 475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.