Sugi Predict

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SCHEMBL18318683

SCHEMBL18318683

COc1ccc2cc(-c3ccc(OC4CCN(C(=O)C5CCCO5)CC4)cc3)cnc2c1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.50
▸ NAMPT P43490 9/20 0.49
▸ PKM P14618 1/20 0.47
▸ PIK3CD O00329 1/20 0.45
▸ PIK3CA P42336 1/20 0.45
▸ HPGDS O60760 1/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ PDGFRB P09619 1/20 0.44
▸ PDGFRA P16234 1/20 0.44
▸ LTA4H P09960 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18318682 1.00 ALDH1A1 (0.50) ALDH1A1NAMPTPKMPIK3CDPIK3CA
SCHEMBL18318458 0.93 ALDH1A1 (0.50) ALDH1A1NAMPTPKMPIK3CDPIK3CA
SCHEMBL18318456 0.93 ALDH1A1 (0.50) ALDH1A1NAMPTPKMPIK3CDPIK3CA
Hydrochloric Acid SCHEMBL28554356 0.92 ALDH1A1 (0.49) ALDH1A1NAMPTPKMPIK3CDPIK3CA
SCHEMBL18319309 0.92 NAMPT (0.49) ALDH1A1NAMPTLTA4H
SCHEMBL18319308 0.92 NAMPT (0.49) ALDH1A1NAMPTLTA4H
Hydrochloric Acid SCHEMBL28554888 0.91 NAMPT (0.49) ALDH1A1NAMPTLTA4H
SCHEMBL18318492 0.90 NAMPT (0.49) ALDH1A1NAMPTPIK3CDPIK3CALTA4H
SCHEMBL18318490 0.90 NAMPT (0.49) ALDH1A1NAMPTPIK3CDPIK3CALTA4H
SCHEMBL18318353 0.88 NAMPT (0.55) ALDH1A1NAMPTPIK3CDPIK3CALTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US claimed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US claimed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN claimed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP claimed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US claimed
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US disclosed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN disclosed
US-10851057-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2020-12-01 — — US disclosed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP disclosed
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2019-05-23 — — US disclosed
US-10221135-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2019-03-05 — — US disclosed
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2018-06-28 — — US disclosed
EP-3310441-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES Cephalon, Inc. (US) 2018-04-25 — — EP disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A ALDH1A1 110/4885NAMPT 491/4885PKM 829/4885
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A ALDH1A1 110/4885NAMPT 491/4885PKM 829/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A ALDH1A1 110/4885NAMPT 491/4885PKM 829/4885
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A ALDH1A1 110/4885NAMPT 491/4885PKM 829/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A ALDH1A1 110/4885NAMPT 491/4885PKM 829/4885
US-10221135-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A ALDH1A1 110/4885NAMPT 491/4885PKM 829/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A ALDH1A1 110/4885NAMPT 491/4885PKM 829/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A ALDH1A1 110/4885NAMPT 491/4885PKM 829/4885
US-10851057-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A ALDH1A1 110/4885NAMPT 491/4885PKM 829/4885
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A ALDH1A1 124/4885NAMPT 475/4885PKM 817/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.