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SCHEMBL18318752

SCHEMBL18318752

CC(C)(C)OC(=O)N1CCC(Oc2ccc(-c3ccnc(Cl)c3)cc2)CC1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 8/20 0.56
▸ CHEK2 O96017 1/20 0.53
▸ PTPN2 P17706 1/20 0.49
▸ PTPN1 P18031 1/20 0.49
▸ PTPN6 P29350 1/20 0.49
▸ WNT3A P56704 1/20 0.47
▸ CACNB4 O00305 2/20 0.47
▸ CACNA1A O00555 2/20 0.47
▸ CACNA1G O43497 2/20 0.47
▸ CACNG3 O60359 2/20 0.47
▸ CACNA1F O60840 2/20 0.47
▸ CACNA1H O95180 2/20 0.47
▸ CACNB3 P54284 2/20 0.47
▸ CACNA2D1 P54289 2/20 0.47
▸ CACNG7 P62955 2/20 0.47
▸ CACNA1B Q00975 2/20 0.47
▸ CACNA1D Q01668 2/20 0.47
▸ CACNB1 Q02641 2/20 0.47
▸ CACNG1 Q06432 2/20 0.47
▸ CACNB2 Q08289 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL190497 0.88 GPR119 (0.53) GPR119CHEK2CACNB4CACNA1ACACNA1G
SCHEMBL29495616 0.88 GPR119 (0.53) GPR119CHEK2CACNB4CACNA1ACACNA1G
SCHEMBL18318210 0.88 GPR119 (0.53) GPR119CHEK2PTPN2PTPN1PTPN6
SCHEMBL18318896 0.88 GPR119 (0.54) GPR119CHEK2PTPN2PTPN1PTPN6
SCHEMBL18318621 0.86 CHEK2 (0.52) GPR119CHEK2PTPN2PTPN1PTPN6
SCHEMBL18318826 0.85 CHEK2 (0.51) GPR119CHEK2PTPN2PTPN1PTPN6
SCHEMBL18318062 0.85 USP30 (0.54) GPR119CHEK2PTPN2PTPN1PTPN6
SCHEMBL18318794 0.82 MAPK10 (0.56) GPR119CHEK2PTPN2PTPN1PTPN6
SCHEMBL18318501 0.82 GPR119 (0.52) GPR119CHEK2PTPN2PTPN1PTPN6
SCHEMBL28912555 0.81 GPR119 (0.51) GPR119CHEK2PTPN2PTPN1PTPN6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
US-20230391723-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2023-12-07 — — US disclosed
US-11702388-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2023-07-18 — — US disclosed
US-20210230116-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2021-07-29 — — US disclosed
CN-107847765-B 1, 4-substituted piperidine derivatives 89生物有限公司 2021-05-04 — — CN disclosed
US-10851057-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2020-12-01 — — US disclosed
EP-3310441-B1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES 89BIO LTD (IL) 2020-07-29 — — EP disclosed
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2019-05-23 — — US disclosed
US-10221135-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2019-03-05 — — US disclosed
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2018-06-28 — — US disclosed
EP-3310441-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES Cephalon, Inc. (US) 2018-04-25 — — EP disclosed
US-9902696-B2 1,4-substituted piperidine derivatives CEPHALON, INC. (US) 2018-02-27 — — US disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A GPR119 223/4885CHEK2 4678/4885PTPN2 4756/4885
US-20190152913-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A GPR119 223/4885CHEK2 4678/4885PTPN2 4756/4885
US-20230391723-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A GPR119 223/4885CHEK2 4678/4885PTPN2 4756/4885
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A GPR119 223/4885CHEK2 4678/4885PTPN2 4756/4885
US-20210230116-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A GPR119 223/4885CHEK2 4678/4885PTPN2 4756/4885
US-10221135-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A GPR119 223/4885CHEK2 4678/4885PTPN2 4756/4885
US-11702388-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A GPR119 223/4885CHEK2 4678/4885PTPN2 4756/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A GPR119 223/4885CHEK2 4678/4885PTPN2 4756/4885
US-10851057-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A GPR119 223/4885CHEK2 4678/4885PTPN2 4756/4885
US-20180179159-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A GPR119 225/4885CHEK2 4673/4885PTPN2 4744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.