SCHEMBL18318924

SCHEMBL18318924

N#CC(C#N)=Cc1ccc(-c2ccc(N(c3ccc(C(=O)O)cc3)c3ccc(-c4ccc(C=C(C#N)C#N)s4)cc3)cc2)s1

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.61
APP P05067 2/20 0.58
TDP1 Q9NUW8 3/20 0.41
POLB P06746 1/20 0.41
APEX1 P27695 1/20 0.41
HTT P42858 1/20 0.41
RECQL P46063 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
HDAC1 Q13547 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
CSNK2A1 P68400 2/20 0.35
PRF1 P14222 2/20 0.35
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
KMT2A Q03164 1/20 0.34
CSNK2A2 P19784 1/20 0.33
CSNK2B P67870 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14762765 0.89 MAPT (0.61) MAPTAPPPOLBL3MBTL1ALDH1A1
SCHEMBL20718508 0.87 MAPT (0.70) MAPTAPPTDP1ALDH1A1HPGD
SCHEMBL21784390 0.86 MAPT (0.63) MAPTAPPTDP1POLBAPEX1
SCHEMBL29898513 0.84 MAPT (0.56) MAPTAPPPOLBALDH1A1KMT2A
SCHEMBL29898512 0.84 MAPT (0.56) MAPTAPPPOLBALDH1A1KMT2A
SCHEMBL25339850 0.81 APP (0.69) MAPTAPPTDP1HDAC1HDAC6
SCHEMBL28643094 0.80 MAPT (0.52) MAPTAPPAPEX1ALDH1A1HPGD
SCHEMBL23836832 0.80 MAPT (0.52) MAPTAPPL3MBTL1ALDH1A1KMT2A
SCHEMBL12673225 0.79 MAPT (0.93) MAPTAPPTDP1ALDH1A1HPGD
SCHEMBL20718538 0.78 MAPT (0.56) MAPTAPPAPEX1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119980313-A Photocathode based on silicon nanowire substrate and preparation method and application thereof 上海大学 2025-05-13 CN disclosed
US-10695723-B2 Dye sensitized photoactive surfaces MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2020-06-30 US disclosed
US-20160367946-A1 DYE SENSITIZED PHOTOACTIVE SURFACES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2016-12-22 US disclosed