SCHEMBL18320574

SCHEMBL18320574

Cc1ccc2nc(-c3cccnc3)cc(C(=O)Nc3c(C)nn(Cc4ccc(C#N)cc4)c3C)c2c1

nearest known ligand 0.72

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 16/20 0.72
SLC2A3 P11169 16/20 0.72
SLC2A4 P14672 15/20 0.72
SLC2A2 P11168 8/20 0.59
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
LMNA P02545 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18320962 0.93 SLC2A1 (0.65) SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL18320675 0.92 SLC2A1 (0.83) SLC2A1SLC2A3SLC2A4SLC2A2CYP2C9
SCHEMBL18320722 0.91 SLC2A1 (0.87) SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL18320785 0.86 SLC2A1 (0.65) SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL16832622 0.85 SLC2A1 (0.78) SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL18320794 0.85 SLC2A1 (0.72) SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL18320796 0.85 SLC2A1 (0.68) SLC2A1SLC2A3SLC2A4SLC2A2MEN1
SCHEMBL18320547 0.85 SLC2A1 (0.74) SLC2A1SLC2A3SLC2A4SLC2A2MEN1
SCHEMBL18320562 0.84 SLC2A1 (0.71) SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL18320724 0.84 SLC2A1 (0.71) SLC2A1SLC2A3SLC2A4SLC2A2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016202898-A1 GLUCOSE TRANSPORT INHIBITORS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-12-22 WO claimed
WO-2016202898-A1 GLUCOSE TRANSPORT INHIBITORS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-12-22 WO disclosed