Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.46 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18318859 | 0.89 | CA12 (0.44) | MAP4K4CSNK1G2CLK4MKNK2MAP4K5 | |
| SCHEMBL30497909 | 0.89 | CA12 (0.44) | MAP4K4CSNK1G2CLK4MKNK2MAP4K5 | |
| Hydrochloric Acid SCHEMBL28550768 | 0.88 | CA12 (0.43) | MAP4K4CSNK1G2CLK4MKNK2MAP4K5 | |
| SCHEMBL18322956 | 0.86 | PRMT5 (0.47) | MAP4K4CSNK1G2CLK4MKNK2MAP4K5 | |
| SCHEMBL18318270 | 0.84 | FASN (0.47) | MAP4K4CSNK1G2CLK4MKNK2MAP4K5 | |
| SCHEMBL18318089 | 0.81 | PIK3CA (0.54) | MAP4K4CSNK1G2CLK4MKNK2MAP4K5 | |
| SCHEMBL22269750 | 0.77 | PDGFRB (0.44) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL28559991 | 0.77 | CA12 (0.46) | MAP4K4CSNK1G2CLK4MKNK2MAP4K5 | |
| SCHEMBL18322929 | 0.76 | CHRNB1 (0.42) | CHRNB1CHRNB2CHRNB4CHRNA3CHRNB3 | |
| SCHEMBL18319268 | 0.76 | FASN (0.46) | MAP4K4PRKCZEPHX2PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310441-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Cephalon, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016205633-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2016-12-22 | — | — | WO | disclosed |