CHRNB1

Acetylcholine receptor subunit beta · P11230 · CHRNB1 on Sugi Atlas →

24,168 patent compounds predicted against CHRNB1, 13,164 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Radafaxine (SCHEMBL48964)	1.00	19/20
SCHEMBL1283154	0.43	11/20
SCHEMBL559942	0.48	9/20
SCHEMBL559943	0.48	9/20
SCHEMBL676032	1.00	6/20
Fumaric Acid (SCHEMBL237911)	0.80	6/20
Fumaric Acid (SCHEMBL237912)	0.80	6/20
SCHEMBL240780	0.58	6/20
Bupropion (SCHEMBL38777)	1.00	5/20
Bupropion (SCHEMBL60314)	1.00	5/20
Bupropion (SCHEMBL300444)	1.00	5/20
SCHEMBL634327	1.00	5/20
SCHEMBL905212	1.00	5/20
SCHEMBL905222	1.00	5/20
Bupropion (SCHEMBL41602)	0.97	5/20
Bupropion (SCHEMBL636116)	0.97	5/20
Bupropion (SCHEMBL1237221)	0.97	5/20
Bupropion (SCHEMBL678781)	0.94	5/20
Bupropion (SCHEMBL1237589)	0.86	5/20
Bupropion (SCHEMBL1235744)	0.84	5/20

Clinical trials — most relevant to CHRNB1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy of the Use of Genetic Markers in the Choice of the Pharmacological Treatment of Smoking (GENTSMOKING)	PHASE4	COMPLETED
Galantamine for Cognition in People With Schizophrenia	PHASE4	COMPLETED
Anti-inflammatory Effects of Tiotropium in Patients with Stable COPD	PHASE4	COMPLETED
Efficacy Study of Galantamine for Cognitive Impairments in Schizophrenia	PHASE4	COMPLETED
Transcranial Magnetic Stimulation in Patients with Dual Disorders	PHASE3	NOT_YET_RECRUITING
Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease Experiments 1 & 2 - Proj #3	PHASE2	COMPLETED
Crossover Target Engagement Study of Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease (Project #3 - Experiment 3 [UdallP3E3])	PHASE2	COMPLETED
Pilot Study of Pyridostigmine Upon Immune Activation in HIV-1 Patients Who Have an Inadequate Immune Response	PHASE2	COMPLETED
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition	PHASE2	RECRUITING
Nicotinic Receptors and Schizophrenia	PHASE1/PHASE2	WITHDRAWN
Social Cognition,Attentional Network and Nicotine Drug Dependency - A Pharmacological Clinical Trail	PHASE1/PHASE2	COMPLETED
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder	PHASE2	COMPLETED
Effect of Varenicline on Cognitive Function in Cigarette Smokers With Schizophrenia	PHASE2	COMPLETED
Brain Networks and Addiction Susceptibility	PHASE1	COMPLETED
Nicotinic Receptor Genetic Variation and Alcohol Reward	PHASE1	RECRUITING
Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression	nan	COMPLETED
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia	nan	UNKNOWN
Effects of Prazosin on the Attention-Enhancing Effects of Nicotine	nan	WITHDRAWN
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Nicotinic Receptor Levels After Stopping Smoking	nan	COMPLETED
Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia	nan	COMPLETED
Immunoadsorption Study Mainz in Adults With Post-COVID Syndrome	nan	COMPLETED
Brain Imaging in Alzheimer's Disease	nan	COMPLETED
Single Photon Emission Computed Tomography to Study Receptors in Parkinson's Disease	nan	COMPLETED
Reversal of Neuromuscular Blockade in Thoracic Surgical Patients	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
fMRI Study of Nicotinic Effect on Neurophysiology of Schizophrenia	nan	COMPLETED
Preemptive Oral Gabapentin and Tramadol on Postoperative Pain After Knee Arthroscopy	nan	COMPLETED
Methacholine, Long-acting M-cholinolytic and beta2-agonist on the Activity of Beta-receptors in Healthy Volunteers	nan	UNKNOWN
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CHRNB1 binder may also engage these)

Protein	Name	Similarity
P04758	—	1.000	P04758 →
P25109	—	1.000	P25109 →
P09690	—	1.000	P09690 →
P04760	—	0.994	P04760 →
P18916	—	0.990	P18916 →
P13536	—	0.989	P13536 →
P20782	—	0.987	P20782 →
P02715	—	0.987	P02715 →
P09660	—	0.986	P09660 →
P02713	—	0.986	P02713 →
CHRNE	Acetylcholine receptor subunit epsilon	0.984	landscape →
CHRNG	Acetylcholine receptor subunit gamma	0.984	landscape →
CHRNA7	Neuronal acetylcholine receptor subunit alpha-7	0.977	landscape →
P04759	—	0.977	P04759 →
Q05941	—	0.975	Q05941 →
P54131	—	0.974	P54131 →
P02717	—	0.972	P02717 →
Q866A2	—	0.972	Q866A2 →
P49582	—	0.970	P49582 →
CHRND	Acetylcholine receptor subunit delta	0.970	landscape →
P02716	—	0.969	P02716 →
P25110	—	0.966	P25110 →
Q494W8	—	0.964	Q494W8 →
Q68RJ7	—	0.962	Q68RJ7 →
P22770	—	0.961	P22770 →
Q9JLB5	—	0.961	Q9JLB5 →
P49580	—	0.959	P49580 →
P02714	—	0.957	P02714 →
CHRNB2	Neuronal acetylcholine receptor subunit beta-2	0.956	landscape →
P09484	—	0.956	P09484 →